Column: Shodex IC SI-90 4E

Applications

ion chromatography

Published case study of analytical quality by design method development and validation

Diduco has published a scientific peer-reviewed case study on how modern analytical method development can be performed in the pharmaceutical industry. The work was performed according to quality by design (QbD) principles to establish the design space and robust setpoint of the ion chromatography assay, and then validated according to the guidelines established by the International Council for Harmonization (ICH).

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Ion chromatography of five inorganic anions with and without XAMS suppressor formatted
ion chromatography

Comparing suppressed and non-suppressed ion chromatography

Suppressed ion chromatography with conductivity detection is a powerful and sensitive technique to analyse charged ionic species, especially anions of strong acids. The chemically regenerated membrane suppressor Xenoic® XAMS can enable analysis of such anions down to levels of a few microgram per litre (part per billion, ppb).

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Foscarnet assay calibration with XAMS suppressor and ASUREX-A200
ion chromatography

Modernized assay for foscarnet following ICH guidelines

New assay for the antiviral medication foscarnet which is a DNA polymerase inhibitor that is used to combat herpes viruses, including drug-resistant cytomegalovirus, and to treat patients with HIV as part of salvage therapy. This assay was developed by Diduco to meet the requirements in the ICH guidelines, as a contribution to the United States Pharmacopoeia initiative for modernized monograph methods.

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Alternative method for voriconazole impurity E
ion chromatography

Alternative method for determination of voriconazole impurity E

Voriconazole is an antifungal medication that is included on the WHO Model list of Essential Medicines. During synthesis of the active ingredient a resolving agent for chiral amines is often used, and it is thus necessary that the quality control prove that this substance is not present at harmful levels in the final product.

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I’ll be happy to answer any questions you might have regarding our products and services.

Tobias Jonsson
CEO, PhD in chemistry
Mobile: +46 705783490
E-mail: tobias@diduco.com

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