ASUREX-A200 Regenerator

ion chromatography

Published case study of analytical quality by design method development and validation

Diduco has published a scientific peer-reviewed case study on how modern analytical method development can be performed in the pharmaceutical industry. The work was performed according to analytical quality by design (AQbD) principles to establish the design space and robust setpoint of the ion chromatography assay, and then validated according to the guidelines established by the International Council for Harmonization (ICH).

Effect of EQAX-TC1 trap on retention time stability with hydroxide eluent

ion chromatography

Preserving eluent quality with dedicated storage protected from ambient carbon dioxide

To ensure that liquid chromatography analysis methods meet regulatory demands of retention repeatability as dictated by pharmacopoeia and the ICH guidelines, it is important to protect weakly buffered eluents from ambient carbon dioxide. The formation of carbonate species will otherwise change the pH and strength of the eluent, thus shifting retention.

ion chromatography

Screening of contaminants and forced degradation products in lithium ion battery electrolyte

Electrolytes in rechargeable batteries for cars, mobile phones, and other portable electric devices typically contain negatively charged counterions that together with lithium and a non-aqueous solvent form an ionic liquid. The bis(fluorosulfonyl)imide anion is a rather new ionic liquid constituent which thus need new quality control procedures.

ion chromatography

Analysis of dietary supplement capsules with carnitine using a generic method for counterions

Oral L-carnitine is a dietary supplement that has been shown to reduce fatigue in elderly people with low muscular endurance, but its effects on athletes during physical activity are not well-supported. Although this endogenous compound is well-known for its involvement in the mitochondrial oxidation of long-chain fatty acids, no scientific evidence has been found that carnitine in isolation enhances fat-burning.

ion chromatography

Comparing suppressed and non-suppressed ion chromatography

Suppressed ion chromatography with conductivity detection is a powerful and sensitive technique to analyse charged ionic species, especially anions of strong acids. The chemically regenerated membrane suppressor Xenoic® XAMS can enable analysis of such anions down to levels of a few microgram per litre (part per billion, ppb).

Foscarnet assay calibration with XAMS suppressor and ASUREX-A200

ion chromatography

Modernized assay for foscarnet following ICH guidelines

New preliminary assay for the antiviral medication foscarnet which is a DNA polymerase inhibitor that is used to combat herpes viruses, including drug-resistant cytomegalovirus, and to treat patients with HIV as part of salvage therapy. This method was developed by Diduco to meet the requirements in the ICH guidelines, as a contribution to the United States Pharmacopoeia initiative for modernized monograph methods.

Quantification by USEPA300.1A using Shimadzu Prominence and ShodexICSI504E with XAMS suppressor and ASUREX regenerator

ion chromatography

Quantification of common anions in bottled drinking water according to EPA method 300.1A

Official procedure for quality control of drinking water according to the United States Environmental Protection Agency. This procedure allows quantification of the seven common inorganic anions fluoride, chloride, nitrite, bromide, nitrate, phosphate and sulfate in the ranges recommended by WHO and national authorities.

ion chromatography

Analysis of clodronate related substances according to European Pharmacopoeia monograph

Official quality control method for the first-generation bisphosphonate clodronate, which inhibits bone resorption and is used to treat bone weakness or pain caused by cancer that has spread to the skeleton. This analysis was performed according to the European Pharmacopoeia monograph method which is used to determine related substances that could be present as impurities in the active ingredient.

Pharamaceutical counterions with XAMS suppressor and ASUREX-A200

ion chromatography

Generic method for isocratic separation of fifteen common pharmaceutical counterions

Many medicines and dietary supplements are bases that carry a positive charge, and consequently these small molecules are accompanied by negatively charged counterions. Such anionic excipients may influence the properties of the pharmaceutical formulation and can also influence the effect of the active ingredient since different ion pairs can have different dissolution rates or abilities to penetrate cell walls.

Chloride and sulfate in dietary supplements

ion chromatography

Analysis of dietary supplement capsules with glucosamine using a generic method for counterions

Oral glucosamine is a dietary supplement that is marketed to support the structure and function of joints and claimed to provide pain relief for people with arthritis and osteoarthritis, although there is no clear evidence that its benefit is significantly above placebo.

Alternative method for voriconazole impurity E

ion chromatography

Alternative method for determination of voriconazole impurity E

Voriconazole is an antifungal medication that is included on the WHO Model list of Essential Medicines. During synthesis of the active ingredient a resolving agent for chiral amines is often used, and it is thus necessary that the quality control prove that this substance is not present at harmful levels in the final product.

Hydroxide gradient separation of organic acids and inorganic anions

ion chromatography

Hydroxide gradient elution of organic acids and inorganic anions

Gradient elution is a powerful tool when aiming to separate many compounds having a wide range of different chemical characteristics. Hydroxide gradients are the most common in ion chromatography since they can be converted into pure water with nearly zero conductivity.

ion chromatography

Product: ASUREX-A200 Regenerator

Applications

Published case study of analytical quality by design method development and validation

Preserving eluent quality with dedicated storage protected from ambient carbon dioxide

Screening of contaminants and forced degradation products in lithium ion battery electrolyte

Analysis of dietary supplement capsules with carnitine using a generic method for counterions

Comparing suppressed and non-suppressed ion chromatography

Modernized assay for foscarnet following ICH guidelines

Quantification of common anions in bottled drinking water according to EPA method 300.1A

Analysis of clodronate related substances according to European Pharmacopoeia monograph

Generic method for isocratic separation of fifteen common pharmaceutical counterions

Analysis of dietary supplement capsules with glucosamine using a generic method for counterions

Alternative method for determination of voriconazole impurity E

Hydroxide gradient elution of organic acids and inorganic anions

Generic method for isocratic separation of ten common pharmaceutical counterions

Separation of six inorganic anions using Shodex IC SI-37 4D column

Separation of six inorganic anions using IonPac AS19 column

Separation of seven inorganic anions using ICSep AN2 column

Separation of seven inorganic anions using ICSep AN1 column

Separation of seven inorganic anions using ICSep AN300 column

Talk to us

Service inquiry

OEM Request