Instrument: Shimadzu

Applications
ion chromatography

Determination of fluoride ion to monitor biodegradation of perfluorinated acids

Although perfluoroalkyl substances (PFAS) are known for their persistence in natural ecosystems, there are certain bacterial strains that can help to decompose them. This published scientific paper studied bacterial degradation of certain perfluorocarboxylic acids (PFCAs) and perfluorosulfonic acids (PFSAs) by including ion chromatography analysis of fluoride ions, set up on a HPLC instrument with added suppressed conductivity detection.

Read More »
ion chromatography

Published case study of analytical quality by design method development and validation

Diduco has published a scientific peer-reviewed case study on how modern analytical method development can be performed in the pharmaceutical industry. The work was performed according to analytical quality by design (AQbD) principles to establish the design space and robust setpoint of the ion chromatography assay, and then validated according to the guidelines established by the International Council for Harmonization (ICH).

Read More »
ion chromatography

Separation of glyphosate and related herbicides in aqueous samples

Analysis of glyphosate and related phosphonates acting as systemic herbicides is critical for protecting public health, ensuring regulatory compliance, and monitoring environmental safety. Because these chemicals are persistent, polar, and highly prevalent in agricultural ecosystems, detecting them allows management of dietary exposure and long-term health risks.

Read More »
Amino acids by gradient HILIC-ELSD and TSKgel Amide-80
HILIC

Separation of selected amino acids

Amino acids are the fundamental building blocks of all proteins and therefore essential constituents of many nutritional supplements and can also be present in pharmaceutical formulations. Due to the highly hydrophilic nature and zwitterionic charge at neutral pH of many amino acids and their structurally related degradation products, hydrophilic interaction chromatography is an attractive mode of separation that require no derivatization, while evaporative light scattering enables rather sensitive detection of these poorly light-absorbing compounds.

Read More »
Simple carbohydrates by HILIC-ELSD and Luna Omega Sugar
HILIC

Separation of simple sugars and carbohydrates

Simple carbohydrates are frequent ingredients in drinks, food, dietary supplements and pharmaceutical formulations. One approach to their analysis is hydrophilic interaction chromatography combined with evaporative light scattering detection, although this might be challenging due to the possibility of reducing sugars to mutarotate and thereby change their conformation into other anomers with different retention.

Read More »
Cannabinoids in hemp using Raptor ARC-18
reversed-phase

Analysis of cannabinoids in dried industrial hemp after methanol extraction

The legislation in many countries allow cultivation of industrial hemp provided that the strains do not produce high amounts of tetrahydrocannabinol (THC) and other psychoactive cannabinoids classified as narcotic substances. These strains of cannabis sativa are instead typically rich in compounds such as cannabidiol (CBD) and cannabidiolic acid (CBDA).

Read More »
Cascade reaction monitoring
reversed-phase

Reaction monitoring of enzyme-catalysed one-pot cascade synthesis

The move towards a more sustainable world includes sourcing functional monomers for polymer synthesis from renewable natural products rather than from fossil-based sources. This green chemistry revolution often relies on the development of new reaction procedures efficiently catalysed by enzymes to involve fewer harmful chemicals.

Read More »

Talk to us

I’ll be happy to answer any questions you might have regarding our products and services.

Tobias Jonsson
CEO, PhD in chemistry

OEM Request

Service inquiry