phosphate – Diduco

ion chromatography

Published case study of analytical quality by design method development and validation

Diduco has published a scientific peer-reviewed case study on how modern analytical method development can be performed in the pharmaceutical industry. The work was performed according to quality by design (QbD) principles to establish the design space and robust setpoint of the ion chromatography assay, and then validated according to the guidelines established by the International Council for Harmonization (ICH).

ion chromatography

Screening of contaminants and forced degradation products in lithium ion battery electrolyte

Electrolytes in rechargeable batteries for cars, mobile phones, and other portable electric devices typically contain negatively charged counterions that together with lithium and a non-aqueous solvent form an ionic liquid. The bis(fluorosulfonyl)imide anion is a rather new ionic liquid constituent which thus need new quality control procedures.

Foscarnet assay calibration with XAMS suppressor and ASUREX-A200

ion chromatography

Modernized assay for foscarnet following ICH guidelines

New preliminary assay for the antiviral medication foscarnet which is a DNA polymerase inhibitor that is used to combat herpes viruses, including drug-resistant cytomegalovirus, and to treat patients with HIV as part of salvage therapy. This method was developed by Diduco to meet the requirements in the ICH guidelines, as a contribution to the United States Pharmacopoeia initiative for modernized monograph methods.

Pharamaceutical counterions with XAMS suppressor and ASUREX-A200

ion chromatography

Generic method for isocratic separation of fifteen common pharmaceutical counterions

Many medicines and dietary supplements are bases that carry a positive charge, and consequently these small molecules are accompanied by negatively charged counterions. Such anionic excipients may influence the properties of the pharmaceutical formulation and can also influence the effect of the active ingredient since different ion pairs can have different dissolution rates or abilities to penetrate cell walls.

Hydroxide gradient separation of organic acids and inorganic anions

ion chromatography

Hydroxide gradient elution of organic acids and inorganic anions

Gradient elution is a powerful tool when aiming to separate many compounds having a wide range of different chemical characteristics. Hydroxide gradients are the most common in ion chromatography since they can be converted into pure water with nearly zero conductivity.

ion chromatography

Analyte: phosphate

Applications

Published case study of analytical quality by design method development and validation

Screening of contaminants and forced degradation products in lithium ion battery electrolyte

Modernized assay for foscarnet following ICH guidelines

Generic method for isocratic separation of fifteen common pharmaceutical counterions

Hydroxide gradient elution of organic acids and inorganic anions

Generic method for isocratic separation of ten common pharmaceutical counterions

Separation of nine inorganic anions including chlorite and bromate using Shodex IC SI-52 4E column

Separation of seven inorganic anions using ICSep AN2 column

Separation of seven inorganic anions using ICSep AN1 column

Separation of six inorganic anions using Metrosep A Supp 10 column

Separation of seven inorganic anions using Metrosep A Supp 16 column

Separation of seven inorganic anions using ICSep AN300 column

Separation of seven anions and acetate using IonPac AS22 column

Separation of seven anions and acetate using IonPac AS14 column

Separation of seven inorganic anions using IonPac AS4A-SC column

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